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KMID : 0357919760100010033
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Korean Journal of Pathology
1976 Volume.10 No. 1 p.33 ~ p.46
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An Epidemiological Study of Primary Liver Carcinomas in Busan Area with Special Reference to Clonorchiasis
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Abstract
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This study was undertaken to investigate the relationship of primary liver carcinoma
and clonorchiasis in Busan area, one of the areas most heavily infested with Clonorchis
sinensis in the southern part of Korea. A series of consecutive 368 cases of primary
liver carcinoma which were subjected to pathological evaluation in our department of
pathology during the years from 1963 to 1974. The cases were mostly derived from
Busan National University Hospital and Busan Gospel Hospital. The diagnosis was
established by gross observation at operation table and morphological examination of the
biopsied livers. The cases were analyzed statistically from an epidemiological view of
point and obtained following results :
1. The relative risk of Clonorchis sinensis infestation in cholangiocarcinoma compared
to hepatocarcinoma is about 5. The prevalence rate of clonorchaisis sinensis is much
higher in cholangiocarcinoma than in cases without primary liver carcinoma, but it is
not so with hepatocarcinomas .
2. The average age of the cases with cholangiocarcinoma and with hepatocarcinoma is
52 and 47, correspondingly, the difference being 5 years. No such marked difference
between the average ages of both types of primary liver carcinomas is found in the
reports by foreign authors. The average age of the cases with primary liver carcinomas
is not associated with Clonorchis infestation and sex, but with its histological type. The
average age of primary liver carcinoma is 48 and is much younger than those of
Japanese and American white cases.
3. The ratio of primary liver carcinoma of male to female is 3.7, almost equal to those
in Japanese and American white.
4. The frequency ratio of the hepatocarcinomas to the cholangiocarcinomas in cases
with clonor. Chiasis was 1.5 and that in cases without clonorchiasis 8.4.
On the basis of the above it seems to be of importance to consider clonorchiasis
sinensis in epidemiological studies of liver cancer in Korea where this parasitic disease
prevails widely.
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KEYWORD
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